PIEZO2, a mechanosensor in the urinary bladder
نویسندگان
چکیده
The functions of the lower urinary tract to store and eliminate urine are regulated by complex neural pathways that coordinate activity smooth striated muscles bladder, urethra, urethral sphincters. 1 de Groat W.C. Yoshimura N. Afferent nerve regulation bladder function in health disease. Handb Exp Pharmacol. 2009; 194: 91-138 Crossref PubMed Scopus (195) Google Scholar Besides control central nervous system, micturition reflexes triggered filling stretches wall flow urethra triggers a urethra-to-bladder reflex facilitating contraction emptying. Both urothelium mechanically sensitive afferents from dorsal root ganglia involved stretch pressure detection. identity molecular mechanosensor was previously unknown.
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ژورنال
عنوان ژورنال: Kidney International
سال: 2021
ISSN: ['0085-2538', '1523-1755']
DOI: https://doi.org/10.1016/j.kint.2021.02.021